Trying to determine where the gene is located and how far apart 2 genes are from one another.
- crossing over (in prophase I of meiosis)
- linked genes - the probability of recombination <>
- syntenic - genes on the same chromosome
- recombination frequency
- LOD scores
- linkage disequilibrium
- polymorhic markers
Gene cloning:
- find linkage to a known markers;
- identify protein coding regions (computers - promoter areas, exon-intron boundaries, starting codones, CG islands)
- compare DNA sequences of these genes in affected and unaffected individuals.
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